A randomized noninferiority trial of condensed protocols for genetic risk disclosure of Alzheimer's disease.

ABSTRACT:

Introduction

Conventional multisession genetic counseling is currently recommended when disclosing apolipoprotein E (APOE) genotype for the risk of Alzheimer's disease (AD) in cognitively normal individuals. The objective of this study was to evaluate the safety of brief disclosure protocols for disclosing APOE genotype for the risk of AD.

Methods

A randomized, multicenter noninferiority trial was conducted at four sites. Participants were asymptomatic adults having a first-degree relative with AD. A standard disclosure protocol by genetic counselors (SP-GC) was compared with condensed protocols, with disclosures by genetic counselors (CP-GC) and by physicians (CP-MD). Preplanned co-primary outcomes were anxiety and depression scales 12 months after disclosure.

Results

SUBMITTER: Green RC 

PROVIDER: S-EPMC4461546 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature