Modelling the Transport of Nanoparticles under Blood Flow using an Agent-based Approach.

ABSTRACT: Blood-mediated nanoparticle delivery is a new and growing field in the development of therapeutics and diagnostics. Nanoparticle properties such as size, shape and surface chemistry can be controlled to improve their performance in biological systems. This enables modulation of immune system interactions, blood clearance profile and interaction with target cells, thereby aiding effective delivery of cargo within cells or tissues. Their ability to target and enter tissues from the blood is highly dependent on their behaviour under blood flow. Here we have produced an agent-based model of nanoparticle behaviour under blood flow in capillaries. We demonstrate that red blood cells are highly important for effective nanoparticle distribution within capillaries. Furthermore, we use this model to

SUBMITTER: Fullstone G 

PROVIDER: S-EPMC4462051 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature