Constructing lncRNA functional similarity network based on lncRNA-disease associations and disease semantic similarity.

ABSTRACT: Increasing evidence has indicated that plenty of lncRNAs play important roles in many critical biological processes. Developing powerful computational models to construct lncRNA functional similarity network based on heterogeneous biological datasets is one of the most important and popular topics in the fields of both lncRNAs and complex diseases. Functional similarity network construction could benefit the model development for both lncRNA function inference and lncRNA-disease association identification. However, little effort has been attempted to analysis and calculate lncRNA functional similarity on a large scale. In this study, based on the assumption that functionally similar lncRNAs tend to be associated with similar diseases, we developed two novel lncRNA functional similarity cal

SUBMITTER: Chen X 

PROVIDER: S-EPMC4462156 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature