Genome-wide association data suggest ABCB1 and immune-related gene sets may be involved in adult antisocial behavior.

ABSTRACT: Adult antisocial behavior (AAB) is moderately heritable, relatively common and has adverse consequences for individuals and society. We examined the molecular genetic basis of AAB in 1379 participants from a case-control study in which the cases met criteria for alcohol dependence. We also examined whether genes of interest were expressed in human brain. AAB was measured using a count of the number of Antisocial Personality Disorder criteria endorsed under criterion A from the Diagnostic and Statistical Manual of Mental Disorders, 4th Edition (DSM-IV). Participants were genotyped on the Illumina Human 1M BeadChip. In total, all single-nucleotide polymorphisms (SNPs) accounted for 25% of the variance in AAB, although this estimate was not significant (P=0.09). Enrichment tests indicated tha

SUBMITTER: Salvatore JE 

PROVIDER: S-EPMC4462601 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature