Genome-wide methylation study on depression: differential methylation and variable methylation in monozygotic twins.

ABSTRACT: Depressive disorders have been shown to be highly influenced by environmental pathogenic factors, some of which are believed to exert stress on human brain functioning via epigenetic modifications. Previous genome-wide methylomic studies on depression have suggested that, along with differential DNA methylation, affected co-twins of monozygotic (MZ) pairs have increased DNA methylation variability, probably in line with theories of epigenetic stochasticity. Nevertheless, the potential biological roots of this variability remain largely unexplored. The current study aimed to evaluate whether DNA methylation differences within MZ twin pairs were related to differences in their psychopathological status. Data from the Illumina Infinium HumanMethylation450 Beadchip was used to evaluate periphe

SUBMITTER: Cordova-Palomera A 

PROVIDER: S-EPMC4462612 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature