Association of colorectal cancer susceptibility variants with esophageal cancer in a Chinese population.

ABSTRACT:

Aim

To investigate the association between colorectal cancer (CRC) genetic susceptibility variants and esophageal cancer in a Chinese Han population.

Methods

A case-control study was conducted including 360 esophageal cancer patients and 310 healthy controls. Thirty-one single-nucleotide polymorphisms (SNPs) associated with CRC risk from previous genome-wide association studies were analyzed. SNPs were genotyped using Sequenom Mass-ARRAY technology, and genotypic frequencies in controls were tested for departure from Hardy-Weinberg equilibrium using a Fisher's exact test. The allelic frequencies were compared between cases and controls using a χ(2) test. Associations between the SNPs and the risk of esophageal cancer were tested using various genetic models (codominant, domi

SUBMITTER: Geng TT 

PROVIDER: S-EPMC4462730 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature