Analysis of variants and mutations in the human winged helix FOXA3 gene and associations with metabolic traits.

ABSTRACT:

Background/objectives

The forkhead factor Foxa3 is involved in the early transcriptional events controlling adipocyte differentiation and plays a critical function in fat depot expansion in response to high-fat diet regimens and during aging in mice. No studies to date have assessed the potential associations of genetic variants in FOXA3 with human metabolic outcomes.

Subjects/methods

In this study, we sequenced FOXA3 in 392 children, adolescents and young adults selected from several cohorts of subjects recruited at the National Institute of Child Health and Human Development of the National Institutes of Health based on the availability of dual-energy X-ray absorptiometry data, magnetic resonance imaging scans and DNA samples. We assessed the association between variants p

SUBMITTER: Adler-Wailes DC 

PROVIDER: S-EPMC4462767 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature