Proof-of-Principle for Immune Control of Global HIV-1 Reactivation In Vivo.

ABSTRACT:

Background

Emerging data relating to human immunodeficiency virus type 1 (HIV-1) cure suggest that vaccination to stimulate the host immune response, particularly cytotoxic cells, may be critical to clearing of reactivated HIV-1-infected cells. However, evidence for this approach in humans is lacking, and parameters required for a vaccine are unknown because opportunities to study HIV-1 reactivation are rare.

Methods

We present observations from a HIV-1 elite controller, not treated with combination antiretroviral therapy, who experienced viral reactivation following treatment for myeloma with melphalan and autologous stem cell transplantation. Mathematical modeling was performed using a standard viral dynamic model. Enzyme-linked immunospot, intracellular cytokine staining,

SUBMITTER: Smith NM 

PROVIDER: S-EPMC4463006 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature