Active Negative Pressure Peritoneal Therapy After Abbreviated Laparotomy: The Intraperitoneal Vacuum Randomized Controlled Trial.

ABSTRACT:

Objective

To determine whether active negative pressure peritoneal therapy with the ABThera temporary abdominal closure device reduces systemic inflammation after abbreviated laparotomy.

Background

Excessive systemic inflammation after abdominal injury or intra-abdominal sepsis is associated with poor outcomes.

Methods

We conducted a single-center, randomized controlled trial. Forty-five adults with abdominal injury (46.7%) or intra-abdominal sepsis (52.3%) were randomly allocated to the ABThera (n = 23) or Barker's vacuum pack (n = 22). On study days 1, 2, 3, 7, and 28, blood and peritoneal fluid were collected. The primary endpoint was the difference in the plasma concentration of interleukin-6 (IL-6) 24 and 48 hours after temporary abdominal closure application.

SUBMITTER: Kirkpatrick AW 

PROVIDER: S-EPMC4463030 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature