Genomic imbalances in pediatric patients with chronic kidney disease.

ABSTRACT:

Background

There is frequent uncertainty in the identification of specific etiologies of chronic kidney disease (CKD) in children. Recent studies indicate that chromosomal microarrays can identify rare genomic imbalances that can clarify the etiology of neurodevelopmental and cardiac disorders in children; however, the contribution of unsuspected genomic imbalance to the incidence of pediatric CKD is unknown.

Methods

We performed chromosomal microarrays to detect genomic imbalances in children enrolled in the Chronic Kidney Disease in Children (CKiD) prospective cohort study, a longitudinal prospective multiethnic observational study of North American children with mild to moderate CKD. Patients with clinically detectable syndromic disease were excluded from evaluation. We c

SUBMITTER: Verbitsky M 

PROVIDER: S-EPMC4463214 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature