Design, synthesis and photochemical properties of the first examples of iminosugar clusters based on fluorescent cores.

ABSTRACT: The synthesis and photophysical properties of the first examples of iminosugar clusters based on a BODIPY or a pyrene core are reported. The tri- and tetravalent systems designed as molecular probes and synthesized by way of Cu(I)-catalysed azide-alkyne cycloadditions are fluorescent analogues of potent pharmacological chaperones/correctors recently reported in the field of Gaucher disease and cystic fibrosis, two rare genetic diseases caused by protein misfolding.

SUBMITTER: Lepage ML 

PROVIDER: S-EPMC4464267 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature