Iridium-catalyzed arylative cyclization of alkynones by 1,4-iridium migration.

ABSTRACT: 1,4-Metal migrations enable the remote functionalization of C-H bonds, and have been utilized in a wide variety of valuable synthetic methods. The vast majority of existing examples involve the 1,4-migration of palladium or rhodium. Herein, the stereoselective synthesis of complex polycycles by the iridium-catalyzed arylative cyclization of alkynones with arylboronic acids is described. To our knowledge, these reactions involve the first reported examples of 1,4-iridium migration.

SUBMITTER: Partridge BM 

PROVIDER: S-EPMC4464530 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature