Eosinophil-dependent skin innervation and itching following contact toxicant exposure in mice.

ABSTRACT:

Background

Contact toxicant reactions are accompanied by localized skin inflammation and concomitant increases in site-specific itch responses. The role(s) of eosinophils in these reactions is poorly understood. However, previous studies have suggested that localized eosinophil-nerve interactions at sites of inflammation significantly alter tissue innervation.

Objective

To define a potential mechanistic link between eosinophils and neurosensory responses in the skin leading to itching.

Methods

BALB/cJ mice were exposed to different contact toxicants, identifying trimellitic anhydride (TMA) for further study on the basis of inducing a robust eosinophilia accompanied by degranulation. Subsequent studies using TMA were performed with wild type versus eosinophil-deficient

SUBMITTER: Lee JJ 

PROVIDER: S-EPMC4464693 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature