Aberrant Activation of the RANK Signaling Receptor Induces Murine Salivary Gland Tumors.

ABSTRACT: Unlike cancers of related exocrine tissues such as the mammary and prostate gland, diagnosis and treatment of aggressive salivary gland malignancies have not markedly advanced in decades. Effective clinical management of malignant salivary gland cancers is undercut by our limited knowledge concerning the key molecular signals that underpin the etiopathogenesis of this rare and heterogeneous head and neck cancer. Without knowledge of the critical signals that drive salivary gland tumorigenesis, tumor vulnerabilities cannot be exploited that allow for targeted molecular therapies. This knowledge insufficiency is further exacerbated by a paucity of preclinical mouse models (as compared to other cancer fields) with which to both study salivary gland pathobiology and test novel intervention str

SUBMITTER: Szwarc MM 

PROVIDER: S-EPMC4464738 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature