Effects of Dry Eye Therapies on Environmentally Induced Ocular Surface Disease.

ABSTRACT:

Purpose

To evaluate the effectiveness of artificial tears and corticosteroids on mitigating the acute ocular surface response to low-humidity environments.

Design

Single-group, crossover clinical trial.

Methods

Twenty subjects with aqueous deficient dry eye were enrolled. Subjects meeting inclusion criteria at visit 1 were exposed to a baseline 90-minute low-humidity environment at visit 2. They then used artificial tears for 2 weeks prior to low-humidity exposure at visit 3, followed by 0.1% dexamethasone for 2 weeks prior to the final low-humidity exposure at visit 4. Outcome measures included corneal and conjunctival staining, blink rate, and irritation symptoms before and after each low-humidity exposure. Digital polymerase chain reaction (PCR) was performed to me

SUBMITTER: Moore QL 

PROVIDER: S-EPMC4464943 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature