Commensal enteric bacteria lipopolysaccharide impairs host defense against disseminated Candida albicans fungal infection.

ABSTRACT: Commensal enteric bacteria maintain systemic immune responsiveness that protects against disseminated or localized infection in extra-intestinal tissues caused by pathogenic microbes. However, as shifts in infection susceptibility after commensal bacteria eradication have primarily been probed using viruses, the broader applicability to other pathogen types remains undefined. In sharp contrast to diminished antiviral immunity, we show commensal bacteria eradication bolsters protection against disseminated Candida albicans fungal infection. Enhanced antifungal immunity reflects more robust systemic expansion of Ly6G(hi)Ly6C(int) neutrophils, and their mobilization into infected tissues among antibiotic-treated compared with commensal bacteria-replete control mice. Reciprocally, depletion of

SUBMITTER: Jiang TT 

PROVIDER: S-EPMC4465067 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature