Enantioselective synthesis of tertiary α-chloro esters by non-covalent catalysis.

ABSTRACT: We report an enantioselective approach to tertiary α-chloro esters through the reaction of silyl ketene acetals and N-chlorosuccinimide. The reaction is promoted by a chiral squaramide catalyst, which is proposed to engage both reagents exclusively through non-covalent interactions. Application of the tertiary chloride products in stereospecific substitution reactions is demonstrated.

SUBMITTER: Liu RY 

PROVIDER: S-EPMC4465138 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature