Systems biology analyses of gene expression and genome wide association study data in obstructive sleep apnea.

ABSTRACT: The precise molecular etiology of obstructive sleep apnea (OSA) is unknown; however recent research indicates that several interconnected aberrant pathways and molecular abnormalities are contributors to OSA. Identifying the genes and pathways associated with OSA can help to expand our understanding of the risk factors for the disease as well as provide new avenues for potential treatment. Towards these goals, we have integrated relevant high dimensional data from various sources, such as genome-wide expression data (microarray), protein-protein interaction (PPI) data and results from genome-wide association studies (GWAS) in order to define sub-network elements that connect some of the known pathways related to the disease as well as define novel regulatory modules related to OSA. Two dis

SUBMITTER: Liu Y 

PROVIDER: S-EPMC4465214 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature