Germline TP53 Mutations in Patients With Early-Onset Colorectal Cancer in the Colon Cancer Family Registry.

ABSTRACT:

Importance

Li-Fraumeni syndrome, usually characterized by germline TP53 mutations, is associated with markedly elevated lifetime risks of multiple cancers, and has been linked to an increased risk of early-onset colorectal cancer.

Objective

To examine the frequency of germline TP53 alterations in patients with early-onset colorectal cancer.

Design, setting, and participants

This was a multicenter cross-sectional cohort study of individuals recruited to the Colon Cancer Family Registry (CCFR) from 1998 through 2007 (genetic testing data updated as of January 2015). Both population-based and clinic-based patients in the United States, Canada, Australia, and New Zealand were recruited to the CCFR. Demographic information, clinical history, and family history data were ob

SUBMITTER: Yurgelun MB 

PROVIDER: S-EPMC4465271 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature