Yeast transcription co-activator Sub1 and its human homolog PC4 preferentially bind to G-quadruplex DNA.

ABSTRACT: Using a G-quadruplex bait, we identified the transcription co-activator Sub1 as a G-quadruplex binding protein by quantitative LC-MS/MS and demonstrated in vivo G-quadruplex binding by ChIP. In vitro, Sub1, and its human homolog PC4, bind preferentially to G-quadruplexes. This provides a possible mechanism by which G-quadruplexes can influence gene transcription.

SUBMITTER: Gao J 

PROVIDER: S-EPMC4465349 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature