Transcriptional coordination of synaptogenesis and neurotransmitter signaling.

ABSTRACT: During nervous system development, postmitotic neurons face the challenge of generating and structurally organizing specific synapses with appropriate synaptic partners. An important unexplored question is whether the process of synaptogenesis is coordinated with the adoption of specific signaling properties of a neuron. Such signaling properties are defined by the neurotransmitter system that a neuron uses to communicate with postsynaptic partners, the neurotransmitter receptor type used to receive input from presynaptic neurons, and, potentially, other sensory receptors that activate a neuron. Elucidating the mechanisms that coordinate synaptogenesis, neuronal activation, and neurotransmitter signaling in a postmitotic neuron represents one key approach to understanding how neurons devel

SUBMITTER: Kratsios P 

PROVIDER: S-EPMC4465358 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature