A genomewide association study points to multiple loci that predict antidepressant drug treatment outcome in depression.

ABSTRACT:

Context

The efficacy of antidepressant drug treatment in depression is unsatisfactory; 1 in 3 patients does not fully recover even after several treatment trials. Genetic factors and clinical characteristics contribute to the failure of a favorable treatment outcome.

Objective

To identify genetic and clinical determinants of antidepressant drug treatment outcome in depression.

Design

Genomewide pharmacogenetic association study with 2 independent replication samples.

Setting

We performed a genomewide association study in patients from the Munich Antidepressant Response Signature (MARS) project and in pooled DNA from an independent German replication sample. A set of 328 single-nucleotide polymorphisms highly related to outcome in both genomewide association stu

SUBMITTER: Ising M 

PROVIDER: S-EPMC4465570 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature