Alteration of mRNA and microRNA expression profiles in rat muscular type vasculature in early postnatal development.

ABSTRACT: The vascular system is characterized by a high degree of plasticity. In particular, functional and structural remodeling of the arterial system takes place during early postnatal development. However, the mechanisms providing such alterations in the rapidly growing organisms are poorly understood, especially for the peripheral vasculature. To explore this, we performed mRNA- and miRNA microarray analysis on muscular type saphenous arteries of young (10-12 days) and adult (2-3 months) rats. Thirty-eight significant pathways (such as oxidative phosphorylation, MAPK signaling, metabolism, cell cycle, DNA replication and focal adhesion) were obtained on differentially regulated genes during postnatal development. Many differentially regulated genes were determined as target- and miRNA-hubs. We

SUBMITTER: Gaynullina D 

PROVIDER: S-EPMC4466593 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature