Unknown

Dataset Information

0

Elevated S100A6 (Calcyclin) enhances tumorigenesis and suppresses CXCL14-induced apoptosis in clear cell renal cell carcinoma.

ABSTRACT: Clear cell renal cell carcinoma (ccRCC) is often resistant to existing therapy. We found elevated S100A6 levels in ccRCC tissues, associated with higher grade pathological features and clinical stages in ccRCC patients. Knockdown of S100A6 inhibited cell proliferation in vitro and tumor growth in vivo. Gene expression profiling suggests a novel function of S100A6 in suppressing apoptosis, as well as a relationship between S100A6 and CXCL14, a pro-inflammatory chemokine. We suggest that the S100A6/CXCL14 signaling pathway is a potential therapeutic target in ccRCC.

SUBMITTER: Lyu XJ 

PROVIDER: S-EPMC4466641 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Elevated S100A6 (Calcyclin) enhances tumorigenesis and suppresses CXCL14-induced apoptosis in clear cell renal cell carcinoma.

Lyu Xiang-Jun XJ   Li Hong-Zhao HZ   Ma Xin X   Li Xin-Tao XT   Gao Yu Y   Ni Dong D   Shen Dong-Lai DL   Gu Liang-You LY   Wang Bao-Jun BJ   Zhang Yu Y   Zhang Xu X  

Oncotarget 20150301 9

Clear cell renal cell carcinoma (ccRCC) is often resistant to existing therapy. We found elevated S100A6 levels in ccRCC tissues, associated with higher grade pathological features and clinical stages in ccRCC patients. Knockdown of S100A6 inhibited cell proliferation in vitro and tumor growth in vivo. Gene expression profiling suggests a novel function of S100A6 in suppressing apoptosis, as well as a relationship between S100A6 and CXCL14, a pro-inflammatory chemokine. We suggest that the S100A  ...[more]

Similar Datasets

Transcriptomics The mechanism of elevated S100A6 (Calcyclin) Enhances Tumorigenesis in clear cell renal cell carcinoma
2013-11-25 | E-GEOD-52708 | biostudies-arrayexpress
Transcriptomics The mechanism of elevated S100A6 (Calcyclin) Enhances Tumorigenesis in clear cell renal cell carcinoma
2013-11-25 | GSE52708 | GEO
Unknown The RNA-binding protein QKI suppresses tumorigenesis of clear cell renal cell carcinoma by regulating the expression of HIF-1α.
| S-EPMC6995368 | biostudies-literature
Unknown Degradation of AZGP1 suppresses apoptosis and facilitates cholangiocarcinoma tumorigenesis via TRIM25.
| S-EPMC10844717 | biostudies-literature
Unknown Targeted inhibition of FAK, PYK2 and BCL-XL synergistically enhances apoptosis in ovarian clear cell carcinoma cell lines.
| S-EPMC3921183 | biostudies-literature
Unknown The oncogene MYBL2 promotes the malignant phenotype and suppresses apoptosis through hedgehog signaling pathway in clear cell renal cell carcinoma.
| S-EPMC10950673 | biostudies-literature
Unknown Moderate DNA hypomethylation suppresses intestinal tumorigenesis by promoting caspase-3 expression and apoptosis.
| S-EPMC8096944 | biostudies-literature
Proteomics NAPRT-mediated deamidated NAD biosynthesis enhances tissue resiliency and suppresses tumorigenesis
2025-12-11 | MSV000100196 | MassIVE
Unknown NEDD4L Suppresses Proliferation and Promotes Apoptosis by Ubiquitinating RAC2 Expression and Acts as a Prognostic Biomarker in Clear Cell Renal Cell Carcinoma.
| S-EPMC11594477 | biostudies-literature
Unknown Upregulation of DACT2 suppresses proliferation and enhances apoptosis of glioma cell via inactivation of YAP signaling pathway.
| S-EPMC5596571 | biostudies-literature