Prenatal choline and the development of schizophrenia.

ABSTRACT:

Background

The primary prevention of illness at the population level, the ultimate aim of medicine, seems out of reach for schizophrenia. Schizophrenia has a strong genetic component, and its pathogenesis begins long before the emergence of psychosis, as early as fetal brain development. Cholinergic neurotransmission at nicotinic receptors is a pathophysiological mechanism related to one aspect of this genetic risk. Choline activates these nicotinic receptors during fetal brain development. Dietary supplementation of maternal choline thus emerges as a possible intervention in pregnancy to alter the earliest developmental course of the illness.

Aim

Review available literature on the relationship of choline supplementation or choline levels during pregnancy and fetal brain dev

SUBMITTER: Freedman R 

PROVIDER: S-EPMC4466850 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature