Dataset Information

Gene-based and pathway-based genome-wide association study of alcohol dependence.

ABSTRACT:

Background

The organization of risk genes within signaling pathways may provide clues about the converging neurobiological effects of risk genes for alcohol dependence.

Aim

Identify risk genes and risk gene pathways for alcohol dependence.

Methods

We conducted a pathway-based genome-wide association study (GWAS) of alcohol dependence using a gene-set-rich analytic approach. Approximately one million genetic markers were tested in the discovery sample which included 1409 European-American (EA) alcohol dependent individuals and 1518 EA healthy comparison subjects. An additional 681 African-American (AA) cases and 508 AA healthy subjects served as the replication sample.