Lipid nanoparticle siRNA treatment of Ebola-virus-Makona-infected nonhuman primates.

ABSTRACT: The current outbreak of Ebola virus in West Africa is unprecedented, causing more cases and fatalities than all previous outbreaks combined, and has yet to be controlled. Several post-exposure interventions have been employed under compassionate use to treat patients repatriated to Europe and the United States. However, the in vivo efficacy of these interventions against the new outbreak strain of Ebola virus is unknown. Here we show that lipid-nanoparticle-encapsulated short interfering RNAs (siRNAs) rapidly adapted to target the Makona outbreak strain of Ebola virus are able to protect 100% of rhesus monkeys against lethal challenge when treatment was initiated at 3 days after exposure while animals were viraemic and clinically ill. Although all infected animals showed evidence of advanc

SUBMITTER: Thi EP 

PROVIDER: S-EPMC4467030 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature