A Comparative Analysis and Review of lysyl Residues Affected by Posttranslational Modifications.

ABSTRACT: Post-translational modification is the most common mechanism of regulating protein function. If phosphorylation is considered a key event in many signal transduction pathways, other modifications must be considered as well. In particular the side chain of lysine residues is a target of different modifications; notably acetylation, methylation, ubiquitylation, sumoylation, neddylation, etc. Mass spectrometry approaches combining highly sensitive instruments and specific enrichment strategies have enabled the identification of modified sites on a large scale. Here we make a comparative analysis of the most representative lysine modifications (ubiquitylation, acetylation, sumoylation and methylation) identified in the human proteome. This review focuses on conserved amino acids, secondary str

SUBMITTER: Cesaro L 

PROVIDER: S-EPMC4467303 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature