Clonal expansion and linear genome evolution through breast cancer progression from pre-invasive stages to asynchronous metastasis.

ABSTRACT: Evolution of the breast cancer genome from pre-invasive stages to asynchronous metastasis is complex and mostly unexplored, but highly demanded as it may provide novel markers for and mechanistic insights in cancer progression. The increasing use of personalized therapy of breast cancer necessitates knowledge of the degree of genomic concordance between different steps of malignant progression as primary tumors often are used as surrogates of systemic disease. Based on exome sequencing we performed copy number profiling and point mutation detection on successive steps of breast cancer progression from one breast cancer patient, including two different regions of Ductal Carcinoma In Situ (DCIS), primary tumor and an asynchronous metastasis. We identify a remarkable landscape of somatic muta

SUBMITTER: Kroigard AB 

PROVIDER: S-EPMC4467391 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature