Activin A inhibits BMP-signaling by binding ACVR2A and ACVR2B.

ABSTRACT:

Background

Activins are members of the TGF-β family of ligands that have multiple biological functions in embryonic stem cells as well as in differentiated tissue. Serum levels of activin A were found to be elevated in pathological conditions such as cachexia, osteoporosis and cancer. Signaling by activin A through canonical ALK4-ACVR2 receptor complexes activates the transcription factors SMAD2 and SMAD3. Activin A has a strong affinity to type 2 receptors, a feature that they share with some of the bone morphogenetic proteins (BMPs). Activin A is also elevated in myeloma patients with advanced disease and is involved in myeloma bone disease.

Results

In this study we investigated effects of activin A binding to receptors that are shared with BMPs using myeloma cell lines wi

SUBMITTER: Olsen OE 

PROVIDER: S-EPMC4467681 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature