Proliferation of preosteoblasts on TiO₂ nanotubes is FAK/RhoA related.

ABSTRACT: Topographies promote surface-dependent behaviors which may positively influence peri-implant bone healing. In this study the topological effects of TiO₂ nanotubes (TNTs) on aspects of preosteoblast behavior was investigated. Specifically, we hypothesize that TNTs can influence cell proliferation of preosteoblasts through cell adhesion and related modulation of FAK and RhoA. By culturing MC3T3-E1 cells on TNTs with different diameters (40nm and 150nm diameters), topography-dependent modulation in cell morphology and cell growth were observed. The average spreading area of the cell on Flat Ti, 40nm TNTs and 150nm TNTs were respectively 2176.05 μm², 1510.44 μm² and 800.72 μm². Proliferation increased among cells cultured on the 150nm TNTs (28.6%) co

SUBMITTER: Zhang H 

PROVIDER: S-EPMC4467958 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature