High-density genotyping of immune loci in Koreans and Europeans identifies eight new rheumatoid arthritis risk loci.

ABSTRACT:

Objective

A highly polygenic aetiology and high degree of allele-sharing between ancestries have been well elucidated in genetic studies of rheumatoid arthritis. Recently, the high-density genotyping array Immunochip for immune disease loci identified 14 new rheumatoid arthritis risk loci among individuals of European ancestry. Here, we aimed to identify new rheumatoid arthritis risk loci using Korean-specific Immunochip data.

Methods

We analysed Korean rheumatoid arthritis case-control samples using the Immunochip and genome-wide association studies (GWAS) array to search for new risk alleles of rheumatoid arthritis with anticitrullinated peptide antibodies. To increase power, we performed a meta-analysis of Korean data with previously published European Immunochip and GWAS

SUBMITTER: Kim K 

PROVIDER: S-EPMC4467986 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature