Visceral adiposity and left ventricular remodeling: The Multi-Ethnic Study of Atherosclerosis.

ABSTRACT:

Background and aims

Visceral fat (VF) is a source of pro-inflammatory adipokines implicated in cardiac remodeling. We sought to determine the impact of visceral fat and subcutaneous fat (SQ) depots on left ventricular (LV) structure, function, and geometry in the Multi-Ethnic Study of Atherosclerosis (MESA).

Methods and results

We performed a post-hoc analysis on 1151 participants from MESA with cardiac magnetic resonance quantification of LV mass and LV mass-to-volume ratio (LVMV, an index of concentricity) and computed tomographic-derived SQ and VF area. Multivariable regression models to estimate association between height-indexed SQ and VF area (per cm(2)/m) with height-indexed LV mass (per height(2.7)) and LVMV were constructed, adjusted for clinical, biochemical, and d

SUBMITTER: Abbasi SA 

PROVIDER: S-EPMC4468023 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature