Abnormal Olfaction in Parkinson's Disease Is Related to Faster Disease Progression.

ABSTRACT:

Introduction

A possible association between olfactory dysfunction and Parkinson's disease (PD) severity has been a topic of contention for the past 40 years. Conflicting reports may be partially explained by procedural differences in olfactory assessment and motor symptom evaluation.

Methods

One hundred and sixty-six nondemented PD patients performed the Brief-Smell Identification Test and test scores below the estimated 20th percentile as a function of sex, age, and education (i.e., 80% specificity) were considered demographically abnormal. Patients underwent motor examination after 12 h without antiparkinsonian medication.

Results

Eighty-two percent of PD patients had abnormal olfaction. Abnormal performance on the Brief-Smell Identification Test was associated with

SUBMITTER: Cavaco S 

PROVIDER: S-EPMC4468273 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature