The cardiovascular implication of single nucleotide polymorphisms of chromosome 9p21 locus among Arab population.

ABSTRACT:

Background

Based on several reports including genome-wide association studies, genetic variability has been linked with higher (nearly half) susceptibility toward coronary artery disease (CAD). We aimed to evaluate the association of chromosome 9p21 single nucleotide polymorphisms (SNPs): rs2383207, rs10757278, and rs10757274 with the risk and severity of CAD among Arab population.

Materials and methods

A prospective observational case-control study was conducted between 2011 and 2012, in which 236 patients with CAD were recruited from the Heart Hospital in Qatar. Patients were categorized according to their coronary angiographic findings. Also, 152 healthy volunteers were studied to determine if SNPs are associated with risk of CAD. All subjects were genotyped for SNPs (rs2

SUBMITTER: El-Menyar AA 

PROVIDER: S-EPMC4468449 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature