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First report of an OXA-48-producing multidrug-resistant Proteus mirabilis strain from Gaza, Palestine.

ABSTRACT: We report the first multidrug-resistant Proteus mirabilis strain producing the carbapenemase OXA-48 (Pm-OXA-48) isolated at Al-Shifa hospital in Gaza, Palestine. Draft genome sequencing of Pm-OXA-48 identified 16 antimicrobial resistance genes, encoding resistance to ?-lactams, aminoglycosides, fluoroquinolones, phenicols, streptothricin, tetracycline, and trimethoprim-sulfamethoxazole. Complete sequencing of the bla(OXA-48)-harboring plasmid revealed that it is a 72 kb long IncL/M plasmid, harboring carbapenemase gene bla(OXA-48), extended spectrum ?-lactamase gene bla(CTX-M-14), and aminoglycoside resistance genes strA, strB, and aph(3')-VIb.

SUBMITTER: Chen L 

PROVIDER: S-EPMC4468693 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature

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First report of an OXA-48-producing multidrug-resistant Proteus mirabilis strain from Gaza, Palestine.

Chen Liang L   Al Laham Nahed N   Chavda Kalyan D KD   Mediavilla Jose R JR   Jacobs Michael R MR   Bonomo Robert A RA   Kreiswirth Barry N BN  

Antimicrobial agents and chemotherapy 20150420 7

We report the first multidrug-resistant Proteus mirabilis strain producing the carbapenemase OXA-48 (Pm-OXA-48) isolated at Al-Shifa hospital in Gaza, Palestine. Draft genome sequencing of Pm-OXA-48 identified 16 antimicrobial resistance genes, encoding resistance to β-lactams, aminoglycosides, fluoroquinolones, phenicols, streptothricin, tetracycline, and trimethoprim-sulfamethoxazole. Complete sequencing of the bla(OXA-48)-harboring plasmid revealed that it is a 72 kb long IncL/M plasmid, harb  ...[more]

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