Chirality- and sequence-selective successive self-sorting via specific homo- and complementary-duplex formations.

ABSTRACT: Self-recognition and self-discrimination within complex mixtures are of fundamental importance in biological systems, which entirely rely on the preprogrammed monomer sequences and homochirality of biological macromolecules. Here we report artificial chirality- and sequence-selective successive self-sorting of chiral dimeric strands bearing carboxylic acid or amidine groups joined by chiral amide linkers with different sequences through homo- and complementary-duplex formations. A mixture of carboxylic acid dimers linked by racemic-1,2-cyclohexane bis-amides with different amide sequences (NHCO or CONH) self-associate to form homoduplexes in a completely sequence-selective way, the structures of which are different from each other depending on the linker amide sequences. The further additi

SUBMITTER: Makiguchi W 

PROVIDER: S-EPMC4468858 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature