The Effect of Cerium Oxide Nanoparticle Valence State on Reactive Oxygen Species and Toxicity.

ABSTRACT: Cerium oxide (CeO2) nanoparticles, which are used in a variety of products including solar cells, gas sensors, and catalysts, are expected to increase in industrial use. This will subsequently lead to additional occupational exposures, making toxicology screenings crucial. Previous toxicology studies have presented conflicting results as to the extent of CeO2 toxicity, which is hypothesized to be due to the ability of Ce to exist in both a +3 and +4 valence state. Thus, to study whether valence state and oxygen vacancy concentration are important in CeO2 toxicity, CeO2 nanoparticles were doped with gadolinium to adjust the cation (Ce, Gd) and anion (O) defect states. The hypothesis that doping would increase toxicity and decrease antioxidant abilities as a result of increased oxygen vacanc

SUBMITTER: Dunnick KM 

PROVIDER: S-EPMC4469090 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature