Proliferating reactive astrocytes are regulated by Notch-1 in the peri-infarct area after stroke.

ABSTRACT:

Background and purpose

The formation of reactive astrocytes is common after central nervous system injuries such as stroke. However, the signaling pathway(s) that control astrocyte formation and functions are poorly defined. We assess the effects of Notch 1 signaling in peri-infarct-reactive astrocytes after stroke.

Methods

We examined reactive astrocyte formation in the peri-infarct area 3 days after distal middle cerebral artery occlusion with or without γ-secretase inhibitor treatment. To directly study the effects of inhibiting a γ-secretase cleavage target in reactive astrocytes, we generated glial fibrillary acidic protein-CreER™:Notch 1 conditional knockout mice.

Results

Gamma-secretase inhibitor treatment after stroke decreased the number of proliferative glia

SUBMITTER: Shimada IS 

PROVIDER: S-EPMC4469355 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature