Calcium and vitamin D supplementation do not influence menopause-related symptoms: Results of the Women's Health Initiative Trial.

ABSTRACT:

Background

It is unknown whether supplementation with calcium and vitamin D has an impact on menopause-related symptoms.

Methods

As part of the Women's Health Initiative Calcium/Vitamin D Supplementation Trial (CaD), women were randomized at 40 clinical sites to elemental calcium carbonate 1000 mg with vitamin D 400 IU daily or placebo. At the CaD baseline visit (year 1 or year 2) and during a mean follow-up of 5.7 years, participants provided data on menopause-related symptoms via questionnaires. Generalized linear mixed effects techniques were used to address research questions.

Results

After excluding participants with missing data (N=2125), we compared menopause-related symptoms at follow-up visits of 17,101 women randomized to CaD with those of 17,056 women given

SUBMITTER: LeBlanc ES 

PROVIDER: S-EPMC4469550 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature