Effect of a pharmacologically induced decrease in core temperature in rats resuscitated from cardiac arrest.

ABSTRACT:

Aim

Hypothermia is recommended by international guidelines for treatment of unconscious survivors of cardiac arrest to improve neurologic outcomes. However, temperature management is often underutilized because it may be difficult to implement. The present study evaluated the efficacy of pharmacologically induced hypothermia on survival and neurological outcome in rats resuscitated from cardiac arrest.

Methods

Cardiac arrest was induced for 10 min in 120 rats. Sixty-one rats were resuscitated and randomized to normothermia, physical cooling or pharmacological hypothermia 5 min after resuscitation. Pharmacological hypothermia rats received a combination of ethanol, vasopressin and lidocaine (HBN-1). Physical hypothermia rats were cooled with intravenous iced saline and coolin

SUBMITTER: Katz LM 

PROVIDER: S-EPMC4469561 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature