The heritability of hemolysis in stored human red blood cells.

ABSTRACT:

Background

The transfusion of red blood cells (RBCs) with maximum therapeutic efficacy is a major goal in transfusion medicine. One of the criteria used in determining stored RBC quality is end-of-storage hemolysis. Between donors, a wide range of hemolysis is observed under identical storage conditions. Here, a potential mechanism for this wide range is investigated. We hypothesize that the magnitude of hemolysis is a heritable trait. Also, we investigated correlations between hemolysis and RBC metabolites; this will establish pathways influencing hemolysis as future targets for genetic analysis.

Study design and methods

Units of RBCs from identical and nonidentical twins were collected and stored under standard conditions for 56 days. Hemolysis, adenosine triphosphate (ATP

SUBMITTER: Van 't Erve TJ 

PROVIDER: S-EPMC4469565 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature