The Effects of Parenteral Amino Acid Therapy on Protein Carbamylation in Maintenance Hemodialysis Patients.

ABSTRACT:

Objective

Protein carbamylation is a urea-driven post-translational protein modification associated with mortality in dialysis patients. Free amino acids (AAs) are competitive inhibitors of protein carbamylation and animal studies suggest increasing AA concentrations reduces carbamylation burden. We hypothesized that AA therapy in maintenance hemodialysis patients would reduce carbamylation, carrying the potential to improve clinical outcomes.

Design

Prospective pilot clinical trial (NCT1612429).

Setting

The study was conducted from March 2013 to March 2014 in outpatient dialysis facilities in the Boston metropolitan area.

Subjects and intervention

We enrolled 23 consecutively consenting hemodialysis subjects, infusing the first 12 individuals with 250 cc of AA

SUBMITTER: Kalim S 

PROVIDER: S-EPMC4469570 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature