Impact of a folic acid-enriched diet on urinary tract function in mice treated with testosterone and estradiol.

ABSTRACT: Aging men are susceptible to developing lower urinary tract symptoms, but the underlying etiology is unknown and the influence of dietary and environmental factors on them is unclear. We tested whether a folic acid-enriched diet changed urinary tract physiology and biology in control male mice and male mice with urinary dysfunction induced by exogenous testosterone and estradiol (T+E2), which mimics changing hormone levels in aging humans. T+E2 treatment increased mouse urine output, time between voiding events, and bladder capacity and compliance. Consumption of a folic acid-enriched diet moderated these changes without decreasing prostate wet weight or threshold voiding pressure. One potential mechanism for these changes involves water balance. T+E2 treatment increases plasma concentrati

SUBMITTER: Keil KP 

PROVIDER: S-EPMC4469891 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature