Detecting reliable cognitive change in individual patients with the MATRICS Consensus Cognitive Battery.

ABSTRACT:

Objective

Clinicians often need to evaluate the treatment response of an individual person and to know that observed change is true improvement or worsening beyond usual week-to-week changes. This paper gives clinicians tools to evaluate individual changes on the MATRICS Consensus Cognitive Battery (MCCB). We compare three different approaches: a descriptive analysis of MCCB test-retest performance with no intervention, a reliable change index (RCI) approach controlling for average practice effects, and a regression approach.

Method

Data were gathered as part of the MATRICS PASS study (Nuechterlein et al., 2008). A total of 159 people with schizophrenia completed the MCCB at baseline and 4weeks later. Data were analyzed using an RCI and a regression formula establishing conf

SUBMITTER: Gray BE 

PROVIDER: S-EPMC4469996 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature