Characterization of glutathione transferases involved in the pathogenicity of Alternaria brassicicola.

ABSTRACT:

Background

Glutathione transferases (GSTs) represent an extended family of multifunctional proteins involved in detoxification processes and tolerance to oxidative stress. We thus anticipated that some GSTs could play an essential role in the protection of fungal necrotrophs against plant-derived toxic metabolites and reactive oxygen species that accumulate at the host-pathogen interface during infection.

Results

Mining the genome of the necrotrophic Brassica pathogen Alternaria brassicicola for glutathione transferase revealed 23 sequences, 17 of which could be clustered into the main classes previously defined for fungal GSTs and six were 'orphans'. Five isothiocyanate-inducible GSTs from five different classes were more thoroughly investigated. Analysis of their catalytic

SUBMITTER: Calmes B 

PROVIDER: S-EPMC4470081 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature