Association study of genes related to bone formation and resorption and the extent of radiographic change in ankylosing spondylitis.

ABSTRACT:

Objective

To identify genetic associations with severity of radiographic damage in ankylosing spondylitis (AS).

Method

We studied 1537 AS cases of European descent; all fulfilled the modified New York Criteria. Radiographic severity was assessed from digitised lateral radiographs of the cervical and lumbar spine using the modified Stoke Ankylosing Spondylitis Spinal Score (mSASSS). A two-phase genotyping design was used. In phase 1, 498 single nucleotide polymorphisms (SNPs) were genotyped in 688 cases; these were selected to capture >90% of the common haplotypic variation in the exons, exon-intron boundaries, and 5 kb flanking DNA in the 5' and 3' UTR of 74 genes involved in anabolic or catabolic bone pathways. In phase 2, 15 SNPs exhibiting p<0.05 were genotyped in a furth

SUBMITTER: Cortes A 

PROVIDER: S-EPMC4470170 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature