Synthesis of N-substituted aryl amidines by strong base activation of amines.

ABSTRACT: We describe an efficient method for the direct preparation of N-substituted aryl amidines from nitriles and primary amines. The protocol employs activation of amines by a strong base and provides greater access to a pharmaceutically relevant functional group. This synthetic approach tolerates deactivated nitriles, nitriles with competing substitution sites, and aryl amines.

SUBMITTER: Khalifa MM 

PROVIDER: S-EPMC4470429 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature