Spirastrellolide E: Synthesis of an advanced C(1)-C(24) southern hemisphere.

ABSTRACT: The synthesis of a C(1)-C(24) advanced southern hemisphere fragment towards the total synthesis of spirastrellolide E has been achieved. Highlights of the route include a highly convergent Type I Anion Relay Chemistry (ARC) tactic for fragment assembly, in conjunction with a directed, regioselective gold-catalyzed alkyne functionalization to generate the central unsaturated [6,6]-spiroketal.

SUBMITTER: Sokolsky A 

PROVIDER: S-EPMC4470430 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature