Nitrosopurines en route to potently cytotoxic asmarines.

ABSTRACT: A nitrosopurine ene reaction easily assembles the asmarine pharmacophore and transmits remote stereochemistry to the diazepine-purine hetereocycle. This reaction generates potent cytotoxins which exceed the potency of asmarine A (1.2 μM IC50) and supersede the metabolites as useful leads for biological discovery.

SUBMITTER: Wan KK 

PROVIDER: S-EPMC4470469 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature